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While both Retatrutide and tirzepatide (known commercially as Zepbound) are Eli Lilly products targeting GLP-1 receptors, Retatrutide's additional action on GCG might promote greater appetite reduction and weight loss
While rotating injection sites is recommended to prevent skin irritation, the rate at which your body metabolizes and clears the medication remains consistent regardless of where it was administered
But in this trial, tirzepatide set a very high bar
the downside is larger injection volumes and marginally faster degradation over the 28-day window due to increased water content
Patients near goal weight are often looking for a lower, steady dose rather than continued escalation, and do not see why they would need the full treatment dose forever
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